The structural similarity with statin like lovastatin allowed the comparison, and suggested that 40 might act through inhibition of HMGR as statins. Furthermore, compounds from Plocamium cornutum were evaluated for their antiplasmodial activity against the chloroquine-sensitive P. falciparum strain (Figure 1.17). =Ajuga remota var. It is invasive in parts of North America. Ajuga ( / ə ˈ dʒ uː É¡ ə /), [3] also known as Bugleweed, [4] Ground pine [5] or Carpet bugle, is a genus of about 40–50 species of annual and perennial herbaceous flowering plants in the mint family Lamiaceae, with most species native to Europe, Asia, [6] and Africa, but also two species in southeastern Australia. Macer proposes the herb for all recent wounds and Miller adds the drawing of splinters to wound healing. Additionally, it ameliorated obesity, impaired glucose tolerance, weight gain and other lipid parameters in obese C57BL/6 mice [240]. The bioassays used for clerodane antifeedancy are very similar to the filter paper disk tests described in Section 8.05.5.3.6(ii), and results are usually expressed as the concentration of a solution which, when disks are immersed in it, causes 80–100% protection of the disk from being eaten. The larvae feed on crucifers, but the adults avoid them and feed on the leaves of Clerodendron trichotomum (Verbenaceae), thereby absorbing and sequestering 8 mg per fly of clerodendrin A (175), which makes their surface very bitter and apparently acts to protect them from predators such as birds and lizards (Section 8.05.6.8).344. Diterpene 40 reduced expression levels of GLUT4, PPARγ and C/EBPα and also reduced Akt/mTOR phosphorylation thereby strongly inhibited the factors responsible for early differentiation of adipocytes. In this state-of-the-art review, A. remota as a possible therapeutic tool for malaria is discussed. Table 4. Translation for 'ajuga' in the free English-Dutch dictionary and many other Dutch translations. Rar. More recently, Muller et al. These resistant insects have developed effective detoxification/inactivation mechanisms. Gerard recommends it for worms. canescens (Benth.) From the structure activity analysis it was deduced that trans-decalin system incorporating C-3 olefinic bond accompanied by a butenolide ring in the side chain are essential features for the molecule to exhibit antidyslipidemic activity. English Keyword (fr) Activité biologique Antipaludique Antiparasitaire In vitro Médecine traditionnelle Origine végétale Pharmacognosie Plante médicinale Plasmodium falciparum Ajuga remota Caesalpinia volkensii Caesalpiniaceae Kenya Angiospermae Apicomplexa Dicotyledones Labiatae Protozoa Spermatophyta Afrique Keyword (en) As secondary plant metabolites, phytoecdysteroids stimulate protein synthesis in plants, activate cell mitosis and possibly act as plant growth regulators. The same compound was much less active against S. littoralis (300 ppm on leaf disks of Ricinus communis) or S. exempta (100 ppm on leaf disks of Zea mays).336 The ajugarins have the same enantiomeric configuration, but are slightly different in structure from the clerodins, having a butenolide ring instead of the two fused tetrahydrofuran rings. The Salernitan herbal repeats Musa and Dioscorides, but with different dosages or length of administration of the remedy. These may have some relevance to the differential diagnosis and treatment of head pain and sinusitis. Michel Kenne Tchimene, ... Victor Kuete, in Medicinal Plant Research in Africa, 2013. The respiratory tract is in fact another body system for which betony is recorded as having uses. Treatment and control of malaria have become more difficult with the spread of drug-resistant parasites and insecticide-resistant mosquito vectors. Therefore, any agents able to assuage neuro-inflammation may be first line candidates for the treatment of AD, PD and Amyotrophic Lateral Sclerosis (ALS) and such agents may very well be found among the terpenes engineered by medicinal plants such citronellol from Pelargonium graveolens L’Hér. In Morocco and Algeria, this plant is used in traditional medicine against several diseases especially diabetes (Bellakhdar et al., 1991; Ziyyat et al., 1997; Merzouki et al., 2000; Jouad et al., 2001; El-Hilaly et al., 2003; Tahraoui et al., 2007; Allali et al., 2008; Kemassi et al., 2014; Telli et al., 2016; Youbi et al., 2016; Barkaoui et al., 2017). The most active extract was from Ajuga iva.300 In the same study, 35 neo-clerodanes were tested, and 16 were significantly active with S. littoralis and 13 with S. frugiperda, but there was no correlation between plant activity and their content of known clerodanes.300 This study also showed how antifeedant activity changes from month to month, with maxima in April and October for Teucrium polium and in May and October for Ajuga reptans.300, Clerodanes are antifeedants for a large number of species, especially among the Lepidoptera, but they are feeding stimulants for the turnip sawfly (Athalia rosae, Hymenoptera). Phytochemical characterization could also serve as a base for the development of new chemical compounds. It appears only in those authors drawing from Musa, here Dalechamps, Bauhin, the Old English Herbarium, the Salernitan herbal and Parkinson, who sources Bauhin. Select a category... Ajuga Trustees Checklist Internet Governing Board Crowns Knowledge Bases Soil Fungi Water Supply Plant Leaves Nurseries Schools, Nursery Harmful Algal Bloom Flowers Nurseries, Hospital Cacao Dictionaries, Medical Dictionaries as Topic Dictionaries, Chemical Dictionary Terminology as Topic Dictionaries, Pharmaceutic Potentilla … In the search for new antimalarial drugs, ethnopharmacological sources should merit more attention. By continuing you agree to the use of cookies. (1830) =*Ajuga crenata (Hochst. =Ajuga remota var. The relative configuration was assigned on the basis of the X-ray crystallographic analysis of its acetate derivative. Three other isolated diterpenes 16-oxocleroda-3, 13(14)E-dien-15-oic acid (41), (4 → 2)-abeo-16(R/S)-2,13Z-kolavadien-15,16-olide-3-al (42) and 3β, 16α-dihydroxycleroda-4(18), 13(14)Z-dien-15, 16-olide (43) when tested in the same HFD fed hamster model, did not show promising results. It counters poison and the bites of snakes or any poisonous or rabid animal, when not only taken internally but also applied externally on a plaster. In a recent study, 40 was shown to be the major active constituent of P. longifolia, responsible for its lipid lowering properties by us. It also has 100 catfish and many other herbs and spices. Using the antifeedant index (AI = [(C − T)/(C + T)]% where C and T are the weight of the control and test disks eaten, respectively), at 100 ppm Jodrellin B had an AI of 100, Jodrellin A had an AI of 92, and clerodin had an AI of 74. In Scutellaria, jodrellin B (occurring in S. albida, S. galericulata, S. grossa, S. polyodon, and S. woronowii) and scutecyprol B (found in S. columnae, S. cypria, S. grossa, and S. rubicunda) exhibit the highest antifeedant index against S. littoralis.60,61 From Ajuga pseudoiva leaves, 14,15-dihydro-ajugapitin displayed the highest activity.62 Furthermore, the genus Teucrium is one of the richest sources of clerodane diterpenes.63. Ajuga remota in particular is traditionally used as a herbal remedy for fever and infections, and is prescribed for malaria by 66% of the Kenyan herbalists. (2.2), spirafolide from Laurus nobilis L. (2.2), tanshinone IIA from Salvia miltiorrhiza Bunge (2.3), asiatic acid from Centella asiatica (L.) Urb. Copyright © 2020 Elsevier B.V. or its licensors or contributors. The major phytoecdysteroid is 20-hydroxyecdysone (4), which is also the active moulting hormone of insects (Israili and Lyoussi 2009; Ramazanov 2005; Rharrabe et al. Copyright © 2020 Elsevier B.V. or its licensors or contributors. ex Vatke =Ajuga bracteosa var. Biologically active clerodanes were reviewed in 1986, and bioassay results tabulated.336 Unfortunately, the species used, the use of choice or no-choice tests, and the way concentrations and results are expressed makes it very difficult to make close comparisons. The genus of Ajuga belongs to the family Lamiaceae and contains at least 301 species. Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. However, its use has not been scientifically validated. crenata (Hochst. The hypoglycemic effect of the aerial part of Ajuga iva (L.) Schreb. Jodrellin B had an AI of 83 at 50 ppm, but this fell to 54 at 1 ppm.340 Structures were determined largely by NMR spectroscopy, using nuclear Overhauser effects and COSY techniques. An interestingly different study has concentrated on substances deterrent to leaf-cutting ants. (2.4)., deoxygedunin from Azadirachta indica A. Juss. Definition of አርማጉሳ is Ajuga remota. Eighty-three patients with chronic cholecystitis and cholangitis received stachyglen (total flavonoids from the herb Stachys neglecta) for 3–4 weeks and it was found that stachyglen exerts a choleretic effect (Peleshchuk et al 1974). Ergosterol-5,8-endoperoxide was about threefold as potent (IC50 of 8.2 µM) [77]. This time Serapio repeats the use as well, as does Miller in the 18th century alongside rheumatism, for which conditions a diet drink of betony, wood sage (the hepatotoxic Teucrium scorodonia) and ground-pine Ajuga chamaepitys was recommended. Bulga Kuntze. (1830) =Ajuga bracteosa var. Medical Information Search. Table 1.1. Compounds from Plocamium suhrii were tested for their in vitro antiproliferative effects against WHCO1 esophageal cancer cells using the MTT assay. Also, its absolute stereochemistry was established as 5R, 8R, 9R, 10R at four stereo-centers. Betony in an eclegma, or thick syrup made from honey, sometimes conveyed to the mouth on a root of liquorice which is licked clean, and taken for 9 days eases a cough. FAQ. Translation of ajuga remota in Amharic. Mixed with sheep fat to form an ointment, the herb heals carbuncles. Ajuga (zhivuchka in Russian), a genus of plants of the family Labiatae. Its two known isolates ajugarin-1 and ergosterol-5,8-endoperoxide and a new isolate 8- O -acetylharpagide were evaluated for their in vitro antiplasmodial activity. In the current review, we summarized A. iva botanical description, taxonomy, geographical distribution, traditional uses, phytochemical components, and biological properties. They are perennial or annual herbs with opposite leaves. is a synonym of Ajuga integrifolia Buch.-Ham. Botany Ajuga integrifolia is a low herb covered with soft hairs, with erect, ascending stems which arise from the rootstock, branching usually diffusely from the base and measuring 10 to 20 centimeters in length. These metabolites have attracted considerable attention for their biological activity, which includes piscicidal, trypanocidal, and antibacterial properties. The record derives from WCSP (data supplied on 2012-03-23 ) which reports it as a synonym (record 5380) with original publication details: Pl. Antonyms for ajugas. Stachys alopecuros was included in the 13 most useful herbs alongside three species of Origanum but the position of Stachys officinalis was not given (Stamatis et al 2003). Whorls of tiny, blue-violet flowers appear in mid to late spring on spikes rising above the foliage to 10\". With noun/verb tables for the different cases and tenses links to audio pronunciation and … Selected Bioactive Monoterpenes from African Medicinal Plants, Susan G. Wynn, Barbara J. Fougère, in Veterinary Herbal Medicine, 2007. was confirmed in alloxan (150 mg/kg BW) rat model of diabetes also by (Boudjelal et al., 2015). Revealing the acute and chronic toxicity of any medicinal plant is essential to promote the therapeutic use of the plant. It presents gardeners with a tough decision in plant selection. In light of this, Chapter 3 proposes several plant terpenes for thymoquinone, (2R)-hydroxyneomajucin, ajugaciliatin B, and 11-keto-β-boswellic acid are sources of synthetic derivatives alkaloids for the treatment of these neurodegenerative diseases. Ley’s group have isolated from Scutellaria woronowii (Juz.) Snippet Ajuga is a genus of about 40-50 species of annual and perennial herbaceous flowering plants in the mint family Lamiaceae. Strychnos henningsii Gilg, Ajuga remota Benth., Warbugia ugandensis Sprague and Olea europaea L. The first three species are used in all the five districts while the others are restricted in some of the districts. The present study was therefore, aimed to assess the antihyperglycemic and antihyperlipidemic activities of ethanol extract of A. remota leaves in streptozotocin (STZ) induced diabetic rats. canescens (Benth.) However, the compound exhibited in vitro cytotoxicity against the A431 human skin carcinoma cell line. These indications are once again passed down in full or in part through the Renaissance writers as far as Culpeper before disappearing. In vitro and in vivo pharmacological investigations indicated the potential activity of A. iva extracts and essential oils as antidiabetic, anti-hypercholesterolemic, antioxidant, antibacterial, anticancer, antiviral, insecticide, and litholytic agents (Bouderbala et al., 2008; Boudjelal et al., 2015; Chouitah et al., 2017; Mouheb et al., 2018). Not particularly tolerant of foot traffic. ‘During the autumn, the foliage of tricolour sage and ajuga becomes burnished with bronze, plum, and garnet.’ ‘Other options include ajuga and low-growing herbs such as thyme.’ ‘They left wide strips between large slabs of Arizona flagstone for planting, and filled the spaces with giant ajuga and Lamium maculatum ‘White Nancy’.’ Definition of ajuga remota is አቆራራጭ፣ አርማጉሳ. Pronunciation of Ajuga reptans with 1 audio pronunciation, 2 synonyms, 2 meanings, 3 translations, 1 sentence and more for Ajuga reptans. Clerodane diterpenes are an important diverse class of secondary metabolites characterized by a bicyclic decalin ring system. Ajuga definition: a genus of herbaceous flowering plants in the mint family | Meaning, pronunciation, translations and examples It has been advocated for gastrointestinal, urinary, gynaecological, respiratory, musculoskeletal and skin problems. Examples of neuroprotective terpenes from medicinal plants are thymoquinone from Monarda didyma L. (2.1), bilobalide from Ginkgo biloba L. (2.2), isoatriplicolide tiglate from Paulownia tomentosa (Thunb.) (1E,3R*,4S*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4S*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4R*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (3R*,4S*,5E,7Z)-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4R*,5E,7Z)-1,8-dibromo-3,4-dichloro-3,7-dimethylocta-1,5,7-triene, and (3R*,4S*)-3,4,6,7-tetrachloro-3,7-dimethylocten-1-ene showed greater cytotoxicity (IC50 of 6.6–9.9 µM) than the known cancer drug cisplatin (IC50 of 13 µM) in the cancer cell line [78]. Indications are once again passed down in full or in part through the Renaissance writers as far as before... 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